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TODD EVERHART, MD
Clinical Vice President
Internal Medicine

Dr. Everhart is board-certified in internal medicine. As a fellow of the American College of Physicians, Todd brings over 23 years of experience practicing medicine and over 12 years experience working in clinical development.

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BILL BYROM, PhD
Vice President, Product Intelligence & Positioning

Dr. Byrom has worked in the pharmaceutical industry for 30 years. He has authored over 70 publications and two industry textbooks on electronic patient-reported outcomes (ePRO). His recent scientific work includes the use of wearable technology and bring-your-own-device (BYOD) eCOA in clinical trials

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LEW FREDANE, MD
Clinical Vice President
Neurology

Dr. Fredane serves as the Therapeutic Area Leader for neurology, overseeing Signant’s eCOA, rater training, and quality assurance work. He has experience as a practicing neurologist, clinical assistant professor, and in the drug development for over 15 years.

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JILL PLATKO, PhD
Senior Scientific Advisor

Overseeing Signant's Scientific Advisor team, Dr. Platko provides guidance on electronic data collection for Clinical Outcome Assessments (eCOA) and its associated diaries and questionnaires. Well-versed in best practices and regulatory requirements, Jill also develops training programs and resources for project delivery teams that cater to their specific needs. She's authored countless scientific articles and regularly serves as a panelist for industry webinars.

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DAN DeBONIS
Principal
Endpoint Solutions

Dan is at the forefront of innovation for electronic Clinical Outcome Assessment (eCOA), outcome analytics, and digital technologies. He has authored a patent as well as various publications on clinical research technologies.

JOAN BUSNER, PhD
Clinical Vice President
Pediatrics, Orphan Diseases, Mood & Anxiety

Dr. Busner has over 35 years of experience as an academic psychiatric researcher and psychopharmacology principal investigator, and founded and directed two university psychiatric clinical trials units. Dr. Busner served continuously on University Institutional Review Boards for 20 years. At Signant she has scientific and clinical responsibility for studies in mood, anxiety, pediatrics, and rare/orphan diseases. She has overseen hundreds of trials and trained thousands of raters. Dr. Busner is currently Affiliate Associate Professor of Psychiatry at Virginia Commonwealth University.

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GARY SACHS, MD
Clinical Vice President
Mood Disorders

Dr. Sachs is the Therapeutic Area Leader in bipolar disease and mood disorders at Signant. He lends his extensive experience in rater training and the methodologies of mood and anxiety disorder research to support studies. 

LET'S MEET

We help you reach your study goals.

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DAVID DANIEL, MD
Senior Vice President 
& Chief Medical Officer

Dr. Daniel has over 25 years of experience overseeing rater training and data quality management programs in various settings. He has supervised countless clinical trials for schizophrenia and bipolar disorder. In addition to his work with Signant, David serves as Clinical Professor of Psychiatry at George Washington University. 

Dr. Kott is based in Signant’s Prague office and until recently was Senior Clinical Manager for Europe. Having led the development of the Data Analytics Program for Bracket, he has overseen the design and reporting of data analytics in multiple large schizophrenia studies. For the past seven years, he has also provided training to investigators as an Expert Trainer.

ALAN KOTT, MUDr
Clinical Vice President & Practice Lead, Data Analytics

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MEET THE EXPERTS

Study design

Outcome measure selection

eCOA modality choice

Telemedicine clinician assessments

eCOA design

PRO dossier support

Rater training

Data quality monitoring / analytics

Wearables & sensors selection and implementation

Innovative technology and novel endpoints

At Signant Health, we combine our technology with robust clinical, scientific and regulatory expertise to guide your study from design to regulatory submission ensuring the generation of clinical evidence of the highest quality and integrity.
Our experts advise on all areas of eCOA science and best practice including:

LET'S MEET

We can help you reach your study goals.

PROOF AT THE SPEED OF LIFE

Signant Health is the evidence generation company. We are focused on leveraging software, deep therapeutic and scientific knowledge, and operational expertise to consistently generate quality evidence for clinical studies across traditional, virtual, and hybrid trial models. For more than 20 years, over 400 sponsors and CROs of all sizes – including all of Top 20 pharma – have trusted Signant Health solutions for remote and site-based eCOA, eConsent, RTSM, supply chain management, and data quality analytics. Learn more at  www.signanthealth.com.  


STEPHAN BART, SR MD CPI
Executive Advisor
Infectious Disease, Vaccines, Science & Medicine

Dr. Bart is both Board certified and a Certified Physician Investigator with a broad therapeutic scope including successful completion of more than 450 domestic and international phase 1 through 3 human clinical trials. He has maintained a successful private practice, held faculty positions at Penn State University and the University of Maryland Medical Center, as well as published many articles in prestigious peer reviewed journals. Dr. Bart is an industry key opinion leader in several areas, with extensive focus on advancing vaccine and immunology research over the past decade. 

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DAVID MILLER, MD MA
Clinical Vice President

Dementia, Geriatrics

Dr. Miller is a geriatric psychiatrist by training. He has over 25 years of experience in patient care, clinical research, teaching, and even served as a principal investigator for dementia studies. David currently serves as the Chair of the Alzheimer’s Association Research Roundtable.

STEVEN TARGUM, MD
Scientific Director, 
Schizophrenia & Mood Disorders

Dr. Targum consults widely to the pharmaceutical industry regarding the design and implementation of clinical trials for new psychotropic drugs and the progression of drug development from concept to approval to launch. 
In addition to his work at Signant, Dr. Targum is a Chief Medical Advisor at Prana Biotechnology Ltd. and has served as Chief Medical Officer at several small biotechnology and pharmaceutical companies.

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MANUELA BOSSI, PhD
Scientific Advisor

Dr. Bossi has authored numerous articles on vision neuroscience, focusing on human binocular vision and perception. From questionnaire creation and administration to data best practices and consent, Manuela’s clinical research experience within academic and NHS institutions will guide researchers through trial challenges.

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DANIELLE MIDDLETON, MD PhD
Scientific Advisor

Dr. Middleton brings more than 10 years of valuable clinical experience from working as a doctor and general practitioner in the NHS, which she leverages to guide Signant's clients on clinical assessments. Danielle’s clinical and research experience enables her to advise clients on clinical trial challenges as well as ensure study instruments are implemented according to author requirements and industry best practices.

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ALEXANDRA KALPADAKIS-SMITH, PhD 
Scientific Advisor

Dr. Kalpadakis-Smith leverages her extensive research experience to advise clients on digitalization, capture of clinical outcome assessments (COA) as well as the use of connected health devices in clinical trials. Alex provides expertise on the development of eCOA solutions and study complexities to ensure adherence to protocol requirements and that the latest regulatory and industry guidance is followed. Bringing more than 8 years of experience in cognitive neuroscience research, she works across therapeutic areas, supporting projects from oncology to COVID-19 vaccines.